So to clear this up a bit, Yes we were projection mapping a dome from the outside with 4 projector and Live Update needed to switched on to allow us to get 6 points of Alignment in the Calibration tab on each projector. We were behind on an install and I forgot that Live Update will send all files to all display machines.
This was the root of my problem.
As a work around to a very heavy show file populated by 13 other images being projected by 20 projectors playing a 27-minute show, I opened our original presentation file and performed the 3d projector calibration inside that file and then copied the adjustments over to the show file with all the tweens and cues. Not the best work flow for getting the show up and running but sometimes things do not go as planned!